At any given time, almost 3 million Canadians have serious depression, but less than one third seek help. (1) The main symptoms of depression can be due to a functional deficiency of the brain monoaminergic transmitters norepinephrine, serotonin and dopamine. (2) Supplementation with Organika®’s High Potency SAMe helps support healthy mood balance. Low levels of SAMe have been reported in the cerebrospinal fluid (CSF) of severely depressed patients, and these levels can be increased by oral administration of SAMe. (3) SAMe may help reduce inflammation, stiffness, regenerate cartilage, and lubricate joints and provide pain relief. (4) Features and Benefits: No gluten, Enteric Coated Tablet, Sugar free, Soy Free, Dairy Free, No-GMO’s, No artificial sweeteners or colours, Made in Canada, NPN # 80071979, Dosage: Recommended Dose - (Oral) Adults Only: Take 1 tablet 3 times per day Avoid taking at bedtime Duration of use: Use for a minimum of 2 weeks to see beneficial effects, Servings: 20 day supply , Cautions or Warnings: Consult a health care practitioner if you are taking anti-depressants, hepatotoxic drugs or any other prescription medication; or if symptoms persist or worsen Consult a health care practitioner prior to use if you have cardiovascular disease Do not use if you are pregnant or breastfeeding; or if you have been diagnosed with bipolar disorder Some people may experience anxiety, restlessness, insomnia, and/or a temporary increase in heart rate (tachycardia), in which case discontinue use Flatulence, nausea, vomiting, diarrhea, constipation, dry mouth or headaches may occur, Storage: Store in a cool, dry place, References: 1. http://www.mooddisorderscanada.ca/documents/Consumer%20and%20Family%20Support/Depression.pdf 2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181668/ 3. http://ajcn.nutrition.org/content/76/5/1158S.full.pdf+html 4. https://www.healthstatus.com/health_blog/wellness/sam-e-better-moods-better-mobility/