Calcium is a major mineral best known for its role building and maintaining strong, healthy bones and teeth. Calcium, however, also transports nutrients across cell membranes; produces hormones and enzymes involved in digestion and metabolism; is involved in nerve cell communication; promotes blood clotting and wound healing; and assists with muscle contractions. While this essential mineral plays a role throughout life, it is especially important for growing children and adolescents to help establish bone mass for maintaining strong bones. Emerging research shows that Vitamin D is a major ally in preventing major diseases. This is a classic combination for anyone looking for bone-building calcium with the added benefit of disease-fighting Vitamin D for optimal absorption. This synergistic formula helps to effectively treat and reduce the risk of osteoporosis. Drug Interactions: Calcium and/or vitamin D can interfere with tetracycline antibiotics, anticoagulants, and calcium channel blockers. Consult your physician before use if you are taking any thiazide diuretics, as these can cause extremely high (potentially toxic) levels of calcium in the body. Nutrient Depletions: Calcium can impair the absorption of the mineral iron. Foods high in phosphorus (animal protein and soft drinks) promote urinary loss of calcium. High consumption of caffeine, and excess dietary fat and fibre can inhibit calcium absorption. Calcium and/or vitamin D may be depleted by corticosteroids, bronchodilators, anti-osteoporotics, cholesterol-reducing medications, anti-gout medications, anti-tuberculosis drugs, Histamine (H2) blockers, oral contraceptives, and sulfonamides. Supportive Interactions: Vitamin D enhances calcium absorption. Garlic supplements along with calcium may help reduce high blood pressure. Warnings and Precautions: None known when taken as directed Toxicity, Adverse Warnings and Side Effects: Do not exceed recommended dosage. Excess calcium can contribute to the development of kidney stones, and may cause calcium deposits in the body. Adults: Take 1 caplet daily. Take a few hours before or after taking other medications.